2nd International Adalat® Symposium: New Therapy of Ischemic by W. Lochner (auth.), Professor Dr. Wilhelm Lochner, Wolfgang

By W. Lochner (auth.), Professor Dr. Wilhelm Lochner, Wolfgang Braasch, Günther Kroneberg (eds.)

The First Adalat Symposium held in Tokyo in 1973, awarded vital experimental and medical effects which have been amassed in Europe and Japan with the hot coronary healing agent. the eu scientists had a chance to debate the issues and effects in my opinion with their jap colleagues. the second one Adalat Symposium was once held in Amsterdam inside a 12 months with the aim of bringing jointly as a rule scientists inside Europe. the implications mentioned in Tokyo were prolonged and supplemented via extra stories. Contributions in simple technology are offered, yet most vital are these scientific stories, which aid and expand evidence of the drug's efficacy in people. The editors desire to convey their appreciation to all these liable for contributing to this document and, particularly, to Dr. M. SPENGLER, Dr. F. EBNER and Dr. ok. BRANDAU for his or her editorial support, and to Dr. W. BOTTGER for the guidance of the topic Index. we are hoping that this book could be a beneficial contribution towards conveying details to physicians and scientists. DiisseldorfjWuppertal, Autumn 1975 W. LOCHNER' W BRAASCH' G. KRONEBERG Contents advent: W. LOCHNER current foundation of Coronary treatment: W. LOCHNER. With eleven Figures 2 consultation I. Chemistry and Experimental Pharmacology (Chairmen: A. FLECKENSTEIN and ok. LANDMARK) Pharmacology of Nifedipine: G. KRONEBERG. With eight Figures 12 dialogue feedback 19 The Chemistry of Nifedipine: F. BOSSERT. With nine Figures 20 Pharmacokinetics of Adalat in Animal Experiments: ok. PATZSCHKE, B.

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They have, however, the general disadvantage that satisfactory coronary dilation is achieved only by parenteral administration. Our own research target was therefore clear. In addition to improving the coronary activity, we had to develop a compound that could be taken orally in order to make reasonable prophylactic therapy possible. mo~ ~R' R500CCH2-oTO~Rl R4 1 Fig. 1 We first tackled this problem by varying the heteroatom in the six-membered heterocyclic ring. By this means a favorable change in the metabolization of the compounds could follow.

V. ' Before vagotomy and stellectomy 200 u41 E150 ~'. JJIt • After vagotomy and stellectomy 200 « ~ ! ~ II • l j I' , . < .... La. • ~ I -• ~ • l:J1. 30 jJg/kg Nifedipine. v. -After vagotomy and stellectomy 400 41 III E ~L. 2. v. injections of nifedipine given to a dog before and after vagotomy and stellectomy. Triangular excursions of traces in the records of the A-V conduction time were caused by test stimuli delivered for the measurement of the FRP. g/kg of nifedipine, a dose almost doubling the coronary sinus outflow in the anesthetized dog (CF-ED 100 )(VATER et al.

6]) exerted no effect on the A-V conduction time and the FRP in some dogs (Fig. 3). , 10 times CFED100' nifedipine prolonged slightly both the A-V conduction time and the FRP (Figs. 2 and 3). 4. After the heart had been deprived of the sympathetic tone by bilateral stellectomy plus vagotomy, the A-V conduction time and the FRP were increased by about 20 msec, being about 140 msec and 240 msec, respectively. v. ofnifedipine, CF-ED100' exerted almost no effect on the A-V conduction time and the FRP (Figs.

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