By W. Creutzfeldt (auth.), Prof. Dr. med. Dr. h.c. W. Creutzfeldt (eds.)
New rules for the remedy of diabetes are defined during this quantity. specialists current experimental and medical information on therapy with acarbose, an alpha-glucosidase inhibitor that delays absorption of quickly carbohydrates. Toxicologic, pharmacologic and metabolic results of acarbose are mentioned. A concluding part at the destiny elements of alpha-glucosidase inhibition deals a good evaluation of healing possibilities.
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Additional resources for Acarbose for the Treatment of Diabetes Mellitus
Uco •• Im,/em Aearba .. (ml' Fig. 4. A Increases in plasma glucose concentrations following ingestion of 100 g sucrose without acarbose (0 mg; n = 4) and with 50 mg (n = 4), 100 mg (n = 4), and 150 mg (n"= 1) acarbose. B Changes in the fractional disappearance rate of glucose with the same doses of acarbose as above, expressed as a percentage of the basal rate. C Percentage of glucose appearing in the peripheral circulation with various doses of acarbose. D Degree of malabsorption as reflected by breath hydrogen (Hz) exhalation.
Mehnert: I agree that hyperinsulinemia may be a risk factor for the development of macro angiopathy, and it is an advantage that acarbose can prevent hyperinsulinemia; but I can not follow your interpretation of the Kunkel results. I think the patients with a high insulin dosage had this owing to poor control of their diabetes, and not the other way round. W. Puis: When these studies were done in Frankfurt I don't think anyone knew what happened during hyperinsulinemia. We did not have the term of insulin insensitivity as we now know from the down regulation of insulin receptors or the poor receptor defect.
1977; Folsch et al. 1981), or a conventional breakfast (Hillebrand et al. 1979; Dimitriadis et al. 1982; Puls 1980; Uttenthal et al. 1987) as test meals, acarbose has repeatedly been shown to reduce postprandial blood glucose, serum insulin, C-peptide, and GIP responses in man (Raptis et al. 1982). Thus, the compound has important effects upon the so-called enteroinsular axis (Creutzfeldt and Ebert 1986). Tolerance to acarbose with regard to its effects or blood glucose, serum insulin, and serum GIP responses to an oral sucrose load did not develop during an 8-week period of investigation (Folsch et al.