By D. Perlman (Ed.)
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Extra resources for Advances in Applied Microbiology, Vol. 22
7) and makisterone (11) were degraded by lysed mycelia of Rhizopus arrhizus, R. nigricans, and CurvuZuria lunata to give poststerone (IV) and subsequently rubrosterone (V). Similarly, ponasterone A (111) was converted by Fusurium Zini ATCC 9593 into rubrosterone (V) in 15% yield (Tom and Abul-Hajj, 1975). FIG. 7. Microbial side-chain cleavage of insect molting hormones 44 CHRISTOPH K. A . MARTIN B. CONVERSION OF STEROLS I N THE PRESENCE OF ENZYME INHIBITORS Several research groups worked out procedures for the selective microbial side-chain cleavage of sterols in the presence of enzyme inhibitors.
Flavescens, and M . peregrinum (19-hydroxycholesterolonly). The same organisms (except M . peregrinum) transformed 6/3,19-oxido-4-cholesten-3one and the corresponding sitosterol derivative to a more polar compound was not (not identified)whereas 3/3-acetoxy-5cr-bromo-6/3,19-oxidocholestane metabolized by M . phlei. On the other hand, Lee (1971) reported that addition of 3P-acetoxy-5abromo-6/3,19-oxidocholestaneto a culture of Nocardia sp. ATCC 19,170 resulted in accumulation of 5cr-bromo-6/3,19-oxidoandrostane-3,17-dione.
Therefore, this technique is considered to be useful for the industrial production of 6-APA as well as the continuous method using immobilized penicillin amidase. TRANSFORMATIONS BY IMMOBILIZED MICROBIAL CELLS 23 F. OTHERPRODUCTION OF USEFULCOMPOUNDS Besides the studies described above, as shown in Table I we have further studied the continuous production of useful compounds by employing immobilized microbial cells, and we have applied for patents on these studies as follows. l n these studies, microbial cells can be effectively immobilized by the polyacrylamide method as in the case of E.