By Grüneberg MD
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Extra resources for Antibiotics and Chemotherapy
And Geddes, A. M. (1978). Streptococcal endocarditis: a penicillin alone or a penicillin with an aminoglycoside. J. Antimicrob. , 4, 381 6 Oakley, C. (1978). Use of antibiotics: Endocarditis. Brit. Med. , 2,489 7 Parker, M. T. and Ball, L. C. (1976). Streptococci and aerococci associated with systemic infection in man. J. Med. , 9, 277 8 Hampton, J. R. and Harrison, M. J. G. (1967). Sterile blood cultures in bacterial endocarditis. Q. J. , 36, 167 The Chemotherapy of Infective Endocarditis 27 9 Friedberg, C.
Association of Streptococcus bovis with carcinoma of the colon. New Engl. J. , 297,800 39 Noble, C. , Uttley, A. , Falk, R. H. and Richardson, P. J. (1978). Streptococcus bovis endocarditis and colonic cancer. Lancet, 1,766 40 Cherubin, C. E. and Neu, H. C. (1971). Infective endocarditis at the Presbyterian Hospital in New York City from 1938-1967. Am. J. , 51,83 41 J awetz, E. (1952). Antibiotic synergism and antagonism. Review of experimental evidence. Arch. Intern. , 90,301 42 Robbins, W. C.
The choice of antibiotics for prophylaxis has been recently reviewed by Newsom37 • Staph. epidermidis has an unpredictable sensitivity and is often resistant to methicillin (and therefore cloxacillin and flucloxacillin) which would be predictably effective against Staph. aureus. Interestingly, the use of prophylactic anti-staphylococcal antibiotics does not seem to have resulted in an increase in postoperative endocarditis caused by Gram-negative bacilli or fungi, although there may be an increased isolation rate of Gram-negative bacilli from other sites.