Antituberculosis Drugs by H. A. Offe (auth.), Professor Dr. med. Karl Bartmann (eds.)

By H. A. Offe (auth.), Professor Dr. med. Karl Bartmann (eds.)

This quantity offers in particular with these antituberculosis medicines which handed the preclinical section and feature been or are utilized in the remedy of tuberculosis and different mycobacterial illnesses (except leprosy) in at the very least a few components of the area. regardless of this restrict, there are 14 such medicinal drugs, and for this reason this quantity has reached particularly huge proportions. to avoid it from changing into even better and extra unwidely, such a lot derivatives of antituberculotics were passed over, particularly the place it really is claimed that they supply purely larger bioavailibility or tolerability. basically within the bankruptcy at the chemotherapy of illnesses because of so-called unusual mycobacteria is the medical use of the medicine defined to a undeniable quantity. as well as antituberculotics, additionally mentioned are antimicrobials that have been came upon to be potent opposed to those mycobacteria. The series during which the medicine are defined is ancient, reflecting no longer the time of discovery yet relatively the 1st scientific program. This order used to be chosen for purposes that are now not proper. during this quantity much less emphasis is put on detection, organic or artificial construction of antituberculotics, and structure-activity relationships. by contrast, emphasis is wear the measure, variety, and mechanism of antimyco bacterial task, pharmacokinetics, and biotransformation in animals and guy, on experimental pharmacodynamics, and at the toxicity of antituberculotics used therapeutically.

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15). Its solubility in water is 13% at 22°C and 25% at 37 DC. 5% soluble in methanol and ethanol at 20°C. INH is poorly soluble in organic solvents immiscible with water. It reacts easily with acetone, with the formation of a soluble hydrazone. A very detailed review of the chemical, physico-chemical, and physical properties of isoniazid was published by KRUGER-THIEMER in 1956. Isoniazid can be determined by microbiological and chemical methods. The microbiological techniques are particularly suitable for quantitative assays in tissues.

Chern Commun: 1301-1302 Bycroft BW, Cameron D, Croft LR, Hassanali-Walji A, Johnson AW, Webb T (1971) Total structure of capreomycin I B, a tuberculostatic peptide antibiotic. Nature 231:301302 Herr EB Jr, Haney ME, Pittenger GE, Higgens CE (1960) Isolation and characterization of a new peptide antibiotic. Proc Indiana Acad Sci 69:134 Herr EB Jr, Haney ME, Pittenger GE (1961) Capreomycin: a new peptide antibiotic. 140th Meeting Am Chern Soc, Abstract no 49c Herr EB Jr, Redstone MO (1966) Chemical and physical characterization of capreomycin.

V. Isonicotinic acid hydrazide (Nydrazid) and related compounds. Am Rev Tuberc 65:357-364 Bernstein J, Jambor WP, Lott WA, Pansy F, Steinberg BA, Yale HL (1953 a) Chemotherapy of experimental tuberculosis. IV. Derivatives of isoniazid. Am Rev Tuberc 67:354365 Historical Introduction and Chemical Characteristics of Antituberculosis Drugs 11 Bernstein J, JamborWP, Lott WA, Pansy F, Steinberg BA, Yale HL (1953b) Chemotherapy of experimental tuberculosis. VII. Heterocyclic acid hydrazides and derivatives.

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